Information on dosage, usage, side effects, interactions, and drug comparisons of Estradiol.
Estradiol
This page contains drug information on Estradiol.
The information provided includes the following:
- what is Estradiol
- the possible side effects of Estradiol
- what happens if you miss a dose of Estradiol
- what happens if you overdose with Estradiol
- the most important information about Estradiol
- how to use Estradiol
- other drugs that may affect Estradiol
- what to avoid while using Estradiol
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Generic Name: Estradiol
Brand Names: Estradiol |
What is the most important information I should know about Estradiol? |
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Rare cases of muscle problems and liver problems have been associated with the use of Estradiol and other similar medicines. Contact your doctor immediately if you experience unexplained muscle pain, tenderness, or weakness, Estradiol especially if accompanied by a fever or flulike symptoms or yellowing of the skin or eyes, abdominal pain, unexplained fatigue, dark colored urine or pale colored stools. These may be early symptoms of muscle or liver problems. |
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Do not take Estradiol without first talking to your doctor if you have liver disease. |
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Alcohol and Estradiol can both be damaging to the liver. Alcohol should be used only in moderation. Discuss the use of alcohol with your doctor so that the potential for liver problems can be determined. |
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Do not take Estradiol if you are pregnant, could become pregnant during treatment, or if you are breast-feeding a baby. |
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Estradiol is an HMG CoA reductase inhibitor. Estradiol blocks the production of cholesterol (a type of fat) in the body. |
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Estradiol is used to reduce the total amounts of cholesterol, LDL (bad) cholesterol, triglycerides (another type of fat), and apolipoprotein B (a protein needed to make cholesterol) in your blood. Estradiol (Estradiol) is also used to increase the level of HDL (good) cholesterol in your blood. These actions may reduce the risk of hardening of the arteries, which can lead to heart attacks, stroke, and peripheral vascular disease. |
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Estradiol may also be used for purposes other than those listed in this medication guide. |
What should I discuss with my healthcare provider before taking Estradiol? |
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Do not take Estradiol without first talking to your doctor if you have liver disease. |
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Before taking Estradiol, tell your doctor if you |
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drink alcoholic beverages, |
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have a chronic muscular disease, or |
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You may not be able to take Estradiol, or you may require a dosage adjustment or special monitoring during treatment if you have any of the conditions listed above. |
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Estradiol is in the FDA pregnancy category X. This means that Estradiol is known to cause birth defects if it is taken during pregnancy. Do not take Estradiol if you are pregnant or could become pregnant during treatment. |
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It is not known whether Estradiol passes into breast milk. Do not take Estradiol without first talking to your doctor if you are breast-feeding a baby. |
How should I take Estradiol? |
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Take Estradiol exactly as directed by your doctor. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you. |
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Take each dose with a full glass of water. |
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For the greatest effect, Estradiol is usually taken at bedtime or with an evening meal. Follow your doctor's instructions. |
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Your doctor may want to monitor your liver function with blood tests before starting treatment with Estradiol and every six months after both the start of your treatment and any increase in dose. Depending on the results of these tests, your doctor can determine how much monitoring you will require. |
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Grapefruit and grapefruit juice may interact with Estradiol. The interaction could lead to potentially dangerous effects. Discuss the use of grapefruit and grapefruit juice with your doctor. Do not increase or decrease the amount of grapefruit products in your diet without first talking to your doctor. |
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Eat a low-fat, low-cholesterol diet. To realize beneficial effects from Estradiol, avoid fatty, high-cholesterol foods. |
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It is important to take Estradiol regularly to get the most benefit. |
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Do not stop taking Estradiol without first talking to your doctor. Estradiol may need to be taken on a long-term basis for the treatment of high cholesterol. |
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Your doctor may want you to have blood tests or other medical evaluations during treatment with Estradiol to monitor progress and side effects. |
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Store Estradiol at room temperature away from moisture and heat. |
What happens if I miss a dose? |
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Take the missed dose as soon as you remember. However, if it is almost time for the next dose, skip the missed dose and take only the next regularly scheduled dose. Do not take a double dose of this medication. |
What happens if I overdose? |
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Seek emergency medical attention if an overdose is suspected. |
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Symptoms of a Estradiol overdose include nausea, diarrhea, stomach distress, and indigestion. |
What should I avoid while taking Estradiol? |
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Grapefruit and grapefruit juice may interact with Estradiol. The interaction could lead to potentially dangerous effects. Discuss the use of grapefruit and grapefruit juice with your doctor. Do not increase or decrease the amount of grapefruit products in your diet without first talking to your doctor. |
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Alcohol and Estradiol can both be damaging to the liver. Alcohol should be used only in moderation. Discuss the use of alcohol with your doctor so that the potential for liver problems can be determined. |
What are the possible side effects of Estradiol? |
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Rare cases of muscle problems and liver problems have been associated with the use of Estradiol and other similar medicines. Contact your doctor immediately if you experience unexplained muscle pain, tenderness, or weakness, especially if accompanied by a fever or flulike symptoms or yellowing of the skin or eyes, abdominal pain, unexplained fatigue, dark colored urine or pale colored stools. These may be early symptoms of muscle or liver problems. |
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If you experience any of the following serious side effects, stop taking Estradiol and seek emergency medical attention or contact your doctor immediately: |
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an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives); |
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decreased urine or rust-colored urine; or |
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Other, less serious side effects may be more likely to occur. Continue to take Estradiol and talk to your doctor if you experience |
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gas, bloating, nausea, stomach upset, heartburn, abdominal pain, constipation, or diarrhea; |
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Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome. |
What other drugs will affect Estradiol? |
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Do not take Estradiol without first talking to your doctor if you are taking any of the following medicines: |
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cyclosporine (Sandimmune, Neoral); |
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gemfibrozil (Lopid), clofibrate (Atromid-S), or fenofibrate (Tricor); |
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niacin (Nicolar, Nicobid, Slo-Niacin, others); |
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erythromycin (E-Mycin, E.E.S., Ery-Tab, others) or clarithromycin (Biaxin); |
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cholestyramine (Questran) or colestipol (Colestid); |
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an antifungal medication such as itraconazole (Sporanox), fluconazole (Diflucan), or ketoconazole (Nizoral); |
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digoxin (Lanoxin, Lanoxicaps); |
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a protease inhibitor such as amprenavir (Agenerase), indinavir (Crixivan), nelfinavir (Viracept), ritonavir (Norvir), lopinavir-ritonavir (Kaletra), or saquinavir (Invirase, Fortovase); |
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amiodarone (Cordarone, Pacer one); or |
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verapamil (Calan, Covera-HS, Isoptin, Verelan). |
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You may not be able to take Estradiol, or you may require a dosage adjustment or special monitoring during treatment if you are taking any of the medicines listed above. |
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Drugs other than those listed here may also interact with Estradiol. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines, including vitamins, minerals, and herbal products. |
Where can I get more information? |
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Your pharmacist has additional information about Estradiol written for health professionals that you may read. |
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Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed. |
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Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/ or to serve consumers viewing this service as a supplement to, andEstradiol side effects not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist. |
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